Synthetic promoters are DNA sequences that do not exist in nature and which are designed to regulate the activity of genes, controlling a gene’s ability to produce its own uniquely encoded protein.

Each gene requires a promoter to decode it into a protein. The stronger the promoter the faster the gene can be decoded and as a consequence more protein can be produced. The genome is made up of a myriad of different promoters specific to each gene that have evolved to control gene expression in a particular manner.

Currently, within the biotech industry, naturally occurring promoters are used to drive protein production. However, natural promoters have evolved for biological functions within the context of the organism in question, and as such they were not purpose-designed for applications within the biotech industry. Depending on the promoter and the specific application, natural promoters are not always able to drive a high level of gene expression and may also be lacking in the desired specificity.

Synthetic promoters comprise fragments of natural promoters to form new stretches of DNA sequence that do not exist in nature. Because Synpromics creates libraries of synthetic promoters comprising multiple sequence combinations, it is able to identify stronger and more specific promoters than exist in nature.